N-acetylcysteine (NAC) and in psychodermatological conditions. Is it useful?

Introduction Pathologic grooming disorders can lead to clinically significant distress and functional impairment. Various psychopharmacological nonpharmacological treatments have been used ameliorate the symptoms of these disorders. N-Acetylcysteine (NAC) is a newer modality in treatment has shown promise obsessive-compulsive related Objectives To determine whether NAC useful body-focused repetitive behavior Methods A literature review was carried out PubMed using descriptors: “body-focused behaviour disorders” “grooming AND “N-Acetylcysteine”. Six results were obtained when time limit 5 years. We selected two them for their relevance PICO question. Subsequently, search repeated same descriptors Cochrane Library, Epistemokinos Tripdatabase, which no additional found. Results Overall, thirty-three articles included systematic reviews that we studied, consisted 23 case reports, one series, seven randomized controlled trials. Dosing oral ranged from 450 3,000 mg per day, periods lasted 1 8 months. Side effects uncommon, mild, usually gastrointestinal nature, with severe aggression reported child. Two trials showed improvement trichotillomania excoriation disorder adults. The other performed pediatric population, showing statistical difference. six reports studying patients suffering (one adults infants) included. Only adding Massachusetts General Hospital, Hairpulling Scale (MGH-HPS). Four differences all them. Three trial onicotylomania difference wasn’t consistent after months treatment. Conclusions There are multiple an several clinical supporting both safety efficacy Based on positive preliminary absence serious adverse effects, carrying therapeutical plausible option management this pathology, especially those therapeutic options not effective. Further studies needed develop algorithm elucidate between children disorder. Disclosure Interest None Declared